Description
Viagra
Pharmachologic effect:
The drug restores the normal response to sexual arousal. The very physiological mechanism that provides an erection is impossible without the release of nitric oxide in the cavernous body during sexual stimulation. NO activates a special enzyme called guanylate cyclase, which increases the level of cGMP (cyclic guanosine monophosphate), relaxes the muscles of the cavernous body and increases blood flow in the penis. Sildenafil, the active substance of VIAGRA, is a selective inhibitor of PDE5 (phosphodiesterase type 5), which ensures the breakdown of cGMP in the cavernous body. The drug is characterized by a peripheral effect on the erection of the penis. It is noteworthy that sildenafil does not directly relax the cavernous body, but uses the relaxing function of nitric oxide. It is known that sexual irritation is necessary for the useful pharmacological action of the drug.
The drug is well tolerated in healthy subjects with one
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