Description
TAMOXIMED (TAMOXIFEN)
COMPOSITION AND FORM OF RELEASE:
The drug contains tamoxifen in the form of citrate.
30.4 mg tamoxifen citrate is equivalent to 20 mg tamoximed,
Other Ingredients: lactose monohydrate, corn starch, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide.
PHARMACOLOGICAL PROPERTIES: Pharmacodynamics. Tamoxifen is a potent non-steroidal estrogen antagonist. It may also act as a partial or full estrogen agonist, depending on the target tissues and animal species studied. In humans, the predominantly antiestrogenic effect of tamoxifen is noted.
The antiestrogenic activity of tamoxifen in the human body is due to its binding to the hormone-binding domain of the estrogen receptor. Thus, tamoxifen blocks the action of estradiol.
Pharmacokinetics. When taken orally, tamoxifen is well absorbed. The maximum plasma concentration is observed 4-7 hours after administration, and the equilibrium concentration is reached
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